On behalf of the USPS Great Lakes Area, DPRA researched regulations affecting the management of pharmaceutical waste. Based on our review of the regulations and USPS policy, DPRA prepared a Pharmaceutical Waste Management Plan for each of the five states in the USPS Great Lakes Area. The Waste Management Plans addressed the state-specific hazardous and non-hazardous waste management and wastewater requirements in the context of applicable USPS policies. A supplemental report summarizing the current and pending state and federal regulations and the local POTW regulations affecting the management of pharmaceutical waste was prepared as a reference for environmental management staff at the USPS. DPRA conducted research to determine the most cost effective, environmentally responsible, and compliant waste management methods to assist the USPS with the selection of acceptable waste management methods. The five Pharmaceutical Waste Management Plans were prepared as manuals for USPS facility personnel to use when managing pharmaceuticals encountered in the mail. The management plans included flow charts and detailed descriptions of each step of the approved pharmaceutical waste management methods. The management plans also included appropriate background and reference information including waste management company and USPS contact information necessary to implement sound decisions that are protective of human health and the environment.